Pivmecillinam Hydrochloride is a prodrug of methicillin, characterized by its oral availability and good absorption after oral administration. After oral absorption, it is rapidly hydrolyzed into methicillin by esterase in the body, which binds to penicillin binding protein-2 (PBP-2) and interferes with bacterial cell wall biosynthesis, causing bacterial deformation and cell lysis, thereby exerting antibacterial effects. Clinically applied to urinary tract and respiratory tract infections, it can also be used for the treatment of typhoid fever. Pivmecillinam has stronger activity against gram-negative bacteria than gram-positive bacteria, and has stronger activity against Escherichia coli producing extended spectrum β - lactams (ESBLs). This drug has been on the market abroad for many years, is safe and effective, has a low resistance rate, and has advantages in pharmacoeconomics.
CAS.NO 32886-97-8
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Pivmecillinam Hydrochloride list of impurities (for more information, please click directly)